Drug | Vmax | Km | Cs | R | CMR | Vo | CLimt | % Saturation | % Unsaturation | S/Km |
---|---|---|---|---|---|---|---|---|---|---|
Theophylline* | 17.4 ± 8.7 | 8.5 ± 3.5 | 1.4 ± 0.3 | 0.9 ± 0.8 | 7.6 ± 3.8 | 3.0 ± 1.0 | 2.1 ± 0.3 | 22.6 ± 0.6 | 77.4 ± 13.7 | 0.4 ± 0.3 |
Mibefradil** | 6.8 ± 0.0b | 70.2 ± 0.0a | 1.0 ± 0.0b | 0.0 ± 0.0b | 30.0 ± 0.0b | 0.0 ± 0.0b | 0.1 ± 0.0b | 1.4 ± 0.0b | 98.6 ± 0.0a | 0.01 ± 0.0b |
Voriconazile* | 114.0 ± 0.0a | 1.2 ± 0.0b | 7.7 ± 0.0a | 661.2 ± 0.0a | 49.5 ± 0.0a | 160 ± 0.0a | 99.1 ± 0.0a | 87.0 ± 0.0a | 13.0 ± 0.0b | 6.7 ± 0.0a |
Metronidazole** | 0.45 ± 0.1b | 0.6 ± 0.3b | 0.7 ± 0.3b | −1.1 ± 1.1b | 0.2 ± 0.0b | 2.1 ± 1.9 | 3.1 ± 0.9a | 54.6 ± 2.3a | 45.4 ± 1.9b | 1.2 ± 0.1a |
Isoniazid** | 30.9 ± 0.0a | 1.70 ± 0.0b | 2.5 ± 0.0a | 27.8 ± 0.0a | 13.4 ± 0.0a | 46.3 ± 0.0a | 18.5 ± 0.0b | 60.0 ± 0.0a | 40.0 ± 0.0b | 1.5 ± 0.0a |
Puromicin** | 193.9 ± 0.0a | 0.04 ± 0.0b | 0.0 ± 0.0b | 0.0 ± 0.0b | 84.2 ± 0.0a | 0.0 ± 0.0b | 0.9 ± 0.0b | 0.0 ± 0.0b | 100 ± 0.0a | 0.0 ± 0.0b |
Phenytoin* | 18.1 ± 9.9a | 50.2 ± 40.8a | 0.5 ± 0.5b | 0.1 ± 0.1b | 7.9 ± 4.3 | 0.2 ± 0.0b | 0.2 ± 0.1b | 0.8 ± 0.3b | 99.2 ± 0.3a | 0.01 ± 0.0b |
Thiopental* | 0.9 ± 0.1b | 22.0 ± 2.0a | 1.0 ± 0.0b | 0.0 ± 0.0b | 0.4 ± 0.0b | 0.01 ± 0.0b | 0.04 ± 0.0b | 4.5 ± 0.4b | 95.5 ± 0.4a | 0.05 ± 0.0b |
Thymidine* | 2.5 ± 0.0b | 45.5 ± 0.0a | 1.0 ± 0.0b | 0.0 ± 0.0b | 1.1 ± 0.0b | 0.1 ± 0.0b | 0.1 ± 0.0b | 2.1 ± 0.0b | 97.9 ± 0.0a | 0.02 ± 0.0b |
Thymine* | 2.6 ± 0.0b | 82.5 ± 0.0a | 1.0 ± 0.0b | 0.0 ± 0.0b | 1.1 ± 0.0b | 0.03 ± 0.0b | 0.03 ± 0.0b | 1.2 ± 0.0b | 98.8 ± 0.0a | 0.01 ± 0.0b |
Fluorouracil* | 2.2 ± 0.0b | 39.8 ± 0.0a | 1.0 ± 0.0b | 0.0 ± 0.0b | 0.9 ± 0.0b | 0.1 ± 0.0b | 0.1 ± 0.0b | 2.5 ± 0.0b | 97.5 ± 0.0a | 0.03 ± 0.0b |
Tylosin* | 0.02 ± 0.0b | 0.4 ± 0.0b | 0.6 ± 0.0b | 0.01 ± 0.0b | 0.01 ± 0.0 | 0.03 ± 0.0 | 0.05 ± 0.0 | 61.1 ± 0.0 | 39.0 ± 0.0b | 1.6 ± 0.0a |