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Table 1 Covariate effects on EC50 values

From: Pharmacokinetic-pharmacodynamic modelling of atazanavir in hair among adolescents on antiretroviral treatment in Zimbabwe

Adjusted EC50 value

Estimated EC50 in ng/mg of atazanavir in hair

(95% Confidence Interval)

p-value

EC50: Base model

4.5 (3.5–7.6)

(NA -reference model)

EC50: Follow-up event

3.3 (1.4 - □)

< 0.001

EC50: 100% Self-reported adherence

4.5 (3.5–7.6)

0.304

EC50: 50% Self-reported adherence

4.5 (1.8 – □)

0.304

EC50: Normal BMI-for-age participants

3.8 (2.7–6.8)

0.927

EC50: Overweight participants

3.5 (1.8–7.5)

0.927

EC50: Underweight participants

5.5 (3.5 – □)

0.927

EC50: Mature care-givers

3.8 (2.3–6.4)

0.636

EC50: Full model

2.4 (□ – 5.5)

0.919