Table 1 Modified Histological Activity Index – grading: necro-inflammatory scores
| Â | SCORE |
|---|---|
A. Periportal or periseptal interface hepatitis (piecemeal necrosis) | |
 Absent | 0 |
 Mild (focal, few portal areas) | 1 |
 Mild/moderate (focal, most portal areas) | 2 |
 Moderate (continuous around < 50 % of tracts or septa) | 3 |
 Severe (continuous around > 50 % of tracts or septa) | 4 |
B. Confluent necrosis | |
 Absent | 0 |
 Focal confluent necrosis | 1 |
 Centrolobular necrosis in some areas | 2 |
 Centrolobular necrosis in most areas | 3 |
 Centrolobular necrosis + occasional portal–central (P-C) bridging | 4 |
 Centrolobular necrosis + multiple P-C bridging | 5 |
 Panlobular or multilobular necrosis | 6 |
C. Focal (spotty) lytic necrosis, apoptosis, and focal inflammation | |
 Absent | 0 |
 One focus or less per 10× objective | 1 |
 One to four foci per 10× objective | 2 |
 Five to 10 foci per 10× objective | 3 |
 More than 10 foci per 10× objective | 4 |
D. Portal inflammation | |
 None | 0 |
 Mild, some or all portal areas | 1 |
 Moderate, some or all portal areas | 2 |
 Moderate/marked, all portal areas | 3 |
 Marked, all portal areas | 4 |
Maximum possible score for grading | 18 |