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Fig. 1 | BMC Pharmacology and Toxicology

Fig. 1

From: The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation

Fig. 1

Effect of neostigmine with diclofenac or celecoxib on analgesia in rats. a Tail clip, b and c writhing test, d measuring β-endorphin serum level after 60 min of drug administration, and e correlation between % analgesia of tail clip with serum β-endorphin after 60 min of drug administration showing the same pattern where combination drugs show decrease in analgesic effect compared to neostigmine. Values are presented as mean ± SD. Data are compared with normal [N] (b), positive control [C] (*), neostigmine [Neo] (@), diclofenac [Diclo] (µ), celecoxib [Cele] (ɛ) and neostigmine + diclofenac [Neo + Diclo] (λ), (Mann-Whitney test for comparison) at p < 0.05. [Neo + Cele] neostigmine + celecoxib

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