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Table 5 Multivariate analysis of the association of phosphate levels and hospital mortality in selected subgroups of patients

From: Association between phosphate disturbances and mortality among critically ill patients with sepsis or septic shock

 

Hypophosphatemia group

Hyperphosphatemia group

 

Variable

aOR (95% CI)

p value

aOR (95% CI)

p-value

p-value for interaction

Age (years)

 Age < 67

0.93 (0.52–1.68)

0.81

1.60 (1.01–2.53)

0.05

0.17

 Age > 67

0.84 (0.43–1.66)

0.62

1.71 (1.10–2.70)

0.02

Sex

 Male

0.95 (0.54–1.64)

0.84

1.54 (1.02–2.32)

0.04

0.17

 Female

0.80 (0.38–1.68)

0.56

1.87 (1.11–3.13)

0.02

Chronic respiratory disease

 Yes

0.48 (0.05–4.53)

0.52

1.62 (0.40–6.49)

0.50

0.29

 No

0.93 (0.59–1.46)

0.74

1.64 (1.17–2.30)

0.004

Chronic cardiac disease

 Yes

1.33 (0.53–3.34)

0.54

1.35 (0.74–2.46)

0.33

0.45

 No

0.76 (0.46–1.27)

0.30

1.68 (1.14–2.50)

0.01

Chronic renal disease

 Yes

0.88 (0.06–13.28)

0.92

1.25 (0.30–5.41)

0.76

0.52

 No

0.89 (0.57–1.39)

0.60

1.70 (1.22–2.37)

0.002

Chronic liver disease

 Yes

0.81 (0.10–6.84)

0.85

1.81 (0.36–9.14)

0.48

0.27

 No

0.90 (0.57–1.42)

0.65

1.54 (1.10–2.15)

0.01

Chronic immunosuppression

 Yes

0.76 (0.31–1.87)

0.56

2.30 (1.02–5.22)

0.05

0.88

 No

0.94 (0.56–1.57)

0.82

1.78 (1.24–2.55)

0.002

APACHE II score

  ≤ 23

0.58 (0.30–1.12)

0.10

2.22 (1.32–3.74)

0.003

0.05

  > 23

1.43 (0.75–0.99)

0.28

1.48 (0.99–2.22)

0.06

Diabetes

 Yes

1.06 (0.51–2.21)

0.87

1.59 (0.97–2.58)

0.06

0.38

 No

0.80 (0.46–1.40)

0.43

1.55 (0.98–2.45)

0.06

Vasopressors

 Yes

1.11 (0.61–2.05)

0.73

1.83 (1.22–2.73)

0.004

0.60

 No

0.71 (0.37–1.37)

0.31

1.27 (0.73–2.23)

0.40

ICU duration (days)

  ≤ 5

0.86 (0.43–1.73)

0.68

2.29 (1.35–3.87)

0.002

0.06

  > 5

0.93 (0.52–1.66)

0.81

1.31 (0.87–1.97)

0.20

Estimated GFR

  ≤ 73

0.94 (0.44–2.03)

0.88

1.92 (1.32–2.81)

0.0007

0.14

  > 73

0.81 (0.47–1.40)

0.44

1.17 (0.58–2.35)

0.67

Acute Kidney Injury

 Yes

0.73 (0.19–2.78)

0.65

1.74 (0.95–3.17)

0.07

0.63

 No

0.91 (0.57–1.46)

0.71

1.52 (1.03–2.24)

0.03

Type of admission

 Non-operative

0.85 (0.55–1.33)

0.48

1.66 (1.20–2.30)

0.002

0.70

 Post-operative

6.50 (0.28–151.13)

0.24

1.63 (0.12–22.98)

0.72

  1. aOR adjusted odds ratio, APACHE Acute Physiology and Chronic Health Evaluation, CI confidence interval, GFR glomerular filtration rate, ICU intensive care unit