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Table 3 Cell viability (%) of ibuprofen derivatives (4a-n) at 10 μg/ml

From: New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile

Comp. 24 h 48 h 72 h Comp. 24 h 48 h 72 h
4a 61.36 ± 1.17 59.69 ± 1.23 57.62 ± 1.26 4 h 80.38 ± 1.39 74.95 ± 1.86 64.76 ± 1.42
4b 56.38 ± 1.50 52.01 ± 0.73 38.76 ± 0.76 4i 89.03 ± 0.66 78.43 ± 1.17 77.16 ± 1.47
4c 82.20 ± 1.24 79.39 ± 1.01 69.86 ± 1.86 4j 51.95 ± 1.42 41.04 ± 0.12 41.03 ± 0.62
4d 80.94 ± 0.88 80.74 ± 1.39 76.88 ± 1.61 4 k 92.29 ± 0.33 76.04 ± 0.95 70.97 ± 1.58
4e 84.79 ± 2.01 78.33 ± 0.95 71.19 ± 1.68 4 l 68.71 ± 1.49 62.60 ± 1.14 60.24 ± 1.77
4f 97.51 ± 2.01 90.51 ± 0.66 76.71 ± 1.68 4 m 76.89 ± 2.01 75.77 ± 1.52 61.19 ± 1.05
4 g 85.95 ± 0.89 78.06 ± 1.77 71.47 ± 1.93 4n 95.25 ± 1.74 81.10 ± 0.63 77.68 ± 1.59
Ibuprofen 92.83 ± 2.24 91.65 ± 1.68 90.46 ± 1.12 DMSO 5% 36.43 ± 1.45 14.40 ± 1.00 6.95 ± 0.38