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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: Depressive effectiveness of vigabatrin (γ-vinyl-GABA), an antiepileptic drug, in intermediate-conductance calcium-activated potassium channels in human glioma cells

Fig. 2

Original current traces of single channel activities and the association between single IKCa channel amplitude and membrane potential obtained in the absence (left) and presence of VGB (10 μM). a Original IKCa channel currents obtained with or without the addition of VGB (10 μM). The number shown at the left lower corner of each panel indicates the level of membrane potential relative to the bath. The downward deflection is the opening event of the channel. b The association between single IKCa channel amplitude and membrane potential (i.e., Δvoltage) in the absence (■) and presence (□) of 10 μM VGB (mean ± SEM; n=8–13 for each point). Note that the single-channel conductance of IKCa channels over the voltage range between − 80 and − 40 mV obtained in the absence (32.4 pS) and presence (32.1 pS) of VGB did not differ significantly in human 13–06-MG cells

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