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Table 2 Biochemical parameters of serum and liver in the experimental groups

From: N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test

Groups

Groups (Mean ± SD)

FPG (mg/dl)

Plasma ALT (IU/L)

Plasma AST (IU/L)

Liver ALT (IU/L)

Liver AST (IU/L)

Liver MDA

(μmol/L)

Control

113.9 ±16.98

44.26 ±10.33

153.8 ± 42.11

173,700±45,540

91,180 ± 15,490

8.72 ± 1.46

APAP

95.10 ± 28.76

59.63 ± 15.56

158.8 ± 28.06

167,200± 50,750

92,420 ± 12,430

8.45 ± 2.39

NAC

104.0 ± 29.85

50.62 ± 3.765

137.7 ± 25.91

146,300± 30,530

87,420 ± 16,930

9.44 ± 0.99

AN 200

84.87 ± 36.98

57.30 ± 6.715

163.4 ± 11.25

181,200± 37,140

110,600 ± 16,930

6.91 ± 1.06

AN 400

101.2 ± 31.83

54.92 ± 11.18

171.4 ± 22.01

174,000± 35,010

97,150 ± 13,560

8.30 ± 3.13

AN 600

102.4 ± 38.89

60.37 ± 7.842

153.1 ± 25.58

162,900± 33,460

97,950 ± 20,470

9.81 ± 3.17

  1. The serum and liver level of liver enzyme activity and lipid peroxidation in control saline group (control) acetaminophen (APAP), N-acetylcysteine (NAC) and acetaminophen (300 mg/kg) combination with the various dosage of 200–600 mg/kg of NAC (AN 200, AN 400, AN 600) in rats. There were 8 Sprague-Dawley rats in each group. The data have been mentioned by mean± standard deviation. Each data in the all groups were analyzed through the one-way ANOVA. There were no significant differences