Table 3 Comparison of methadone doses and effect rates in patients with single or co-ingestant exposure of methadone
Complications | Dose of methadone in methadone alone (mg) | Dose of methadone in methadone plus other drugs (mg) | |
|---|---|---|---|
Coma/Central nervous system (CNS) depression | Yes | 96.2 [56.8–125.0] | 97.2 [72.3–136.0] |
No | 65.9 [38.6–84.1] | 124.3 [100.1–168.7] | |
Agitation | Yes | 132.5 [98.3–140.7] | 119.3 [108.9–127.1] |
No | 125.0 [96.2–156.4] | 37.5 [29.8–65.3] | |
No | 66.6 [54.8–89.2] | 121.3 [95.6–163.8] | |
Seizures | Yes | 138.2 [96.5–165.1] | 136.9 [103.6–172.3] |
No | 145.2 [100.2–189.0] | 120.1 [89.6–160.3] | |
Weakness | Yes | 43.7 [35.6–57.6] | 43.6 [32.1–68.9] |
No | 14.2 [9.6–25.6] | 119.6 [100.0–156.3] | |
pH < 7 | Yes | 40.2 [24.3–50.8] | 45 ± 24.2 |
No | 69.8 [57.3–99.2] | 124.3 [100.6–154.9] | |
Bradycardia | Yes | 42.3 [36.8–60.2] | 64.5 [49.6–87.0] |
No | 38.6 [30.1–45.7] | 119.9 [96.3–157.6] | |
Hypertension | Yes | 40.2 [32.3–50.9] | 126.3 [100.5–160.0] |
No | 39.6 [28.9–61.2] | 120.3 [95.6–156.8] | |
Hypotension | Yes | 32.0 [25.3–41.9] | 26.3 [14.6–38.9] |
No | 40.9 [32.9–53.6] | 126.5 [105.3–153.6] | |
Tachycardia | Yes | 74.9 [62.3–90.4] | 147.1 [125.3–175.1] |
No | 36.0 [28.9–51.4] | 123.6 [98.0–168.6] | |
QTc > 500 milliseconds | Yes | 74.2 [52.8–88.6] | 32.1 [29.6–36.5] |
No | 34.5 [28.6–58.9] | 128.7 [106.5–150.6] | |
Acute Kidney injury | Yes | 42.5 [14.8–65.3] | 16.8 [9.8–26.1] |
No | 117.3 [84.0–140.4] | 102.3 [86.7–123.9] | |
Rhabdomyolysis | Yes | 37.5 [29.7–50.0] | 42.3 [19.0–57.8] |
No | 43.8 [34.6–59.9] | 124.3 [97.8–150.1] | |
Aspiration pneumonitis | Yes | 24.6 [16.7–36.8] | 37.8 [26.3–49.0] |
No | 28.6 [14.6–34.5] | 124.8 [100.1–148.6] | |
Respiratory depression | Yes | 80.3 [60.3–100.2] | 46.6 [34.8–67.2] |
No | 128.7 [100.2–168.7] | 108.9 [85.3–125.6] | |
Hepatotoxicity (AST > 1000) | Yes | 45.2 [25.6–59.9] | 43.2 [29.7–60.0] |
No | 62.4 [48.7–81.0] | 122.3 [99.3–145.6] | |