Variable | Total | Single exposure of methadone (n = 354) | Co exposure of Methadone with other drugs (n = 619) |
---|---|---|---|
Coma/CNS | 472 (48.6%) | 354 (100%) | 118 (19.1%) |
Agitation | 69 (7.1%) | 39 (11.1%) | 30 (4.84%) |
Seizures | 21 (2.2%) | 13 (3.67%) | 8 (1.29%) |
Weakness | 6 (0.6%) | 2 (0.56%) | 4 (0.64%) |
pH < 7 | 57 (5.8%) | 43 (12/0%) | 14 (2.26%) |
Bradycardia | 41 (4.2%) | 26 (7.28%) | 15 (2.42%) |
Hypertension | 34 (3.5%) | 24 (6.72%) | 10 (16.1%) |
Hypotension | 38 (3.9%) | 28 (7.91%) | 10 (16.1%) |
Tachycardia | 22 (2.3%) | 13 (3.67%) | 9 (1.45%) |
QTc > 500 milliseconds | 24 (2.9%) | 20 (5.64%) | 4 (0.64%) |
Acute Kidney injury | 92 (9.5%) | 70 (19.7%) | 22 (3.55%) |
Rhabdomyolysis | 43 (4.4%) | 35 (9.88%) | 8 (1.29%) |
Aspiration pneumonitis | 53 (5.4%) | 44 (12.4%) | 9 (1.45%) |
Respiratory depression | 327 (33.6%) | 251 (70.9%) | 76 (12.3%) |
Hepatotoxicity (AST > 1000) | 36 (3.7%) | 28 (7.91%) | 8 (1.29%) |