Skip to main content

Table 2 The percent of clinical effects in methadone alone poisoning and co-ingestion

From: Clinical characteristics and time trends of hospitalized methadone exposures in the United States based on the Toxicology Investigators Consortium (ToxIC) case registry: 2010–2017

Variable

Total

Single exposure of methadone (n = 354)

Co exposure of Methadone with other drugs (n = 619)

Coma/CNS

472 (48.6%)

354 (100%)

118 (19.1%)

Agitation

69 (7.1%)

39 (11.1%)

30 (4.84%)

Seizures

21 (2.2%)

13 (3.67%)

8 (1.29%)

Weakness

6 (0.6%)

2 (0.56%)

4 (0.64%)

pH < 7

57 (5.8%)

43 (12/0%)

14 (2.26%)

Bradycardia

41 (4.2%)

26 (7.28%)

15 (2.42%)

Hypertension

34 (3.5%)

24 (6.72%)

10 (16.1%)

Hypotension

38 (3.9%)

28 (7.91%)

10 (16.1%)

Tachycardia

22 (2.3%)

13 (3.67%)

9 (1.45%)

QTc > 500 milliseconds

24 (2.9%)

20 (5.64%)

4 (0.64%)

Acute Kidney injury

92 (9.5%)

70 (19.7%)

22 (3.55%)

Rhabdomyolysis

43 (4.4%)

35 (9.88%)

8 (1.29%)

Aspiration pneumonitis

53 (5.4%)

44 (12.4%)

9 (1.45%)

Respiratory depression

327 (33.6%)

251 (70.9%)

76 (12.3%)

Hepatotoxicity (AST > 1000)

36 (3.7%)

28 (7.91%)

8 (1.29%)

  1. Values are frequency and percentage
  2. The percentages in the methadone only and methadone plus coingestants are calculated in each group
  3. Abbreviations: AST aspartate aminotransferase, CNS central nervous system