Fig. 1

Images of tumors harvested from the mice after the 20-day experimental period (a); average tumor weight of the mice after 20 days (b). Naringin (60, 120 or 180 mg/kg) administrationnbegan 7 days-after U-87 inoculation-into the right-flank of the nude athymic mice, and theinjection was repeated until-the animals were-sacrificed. Chemopreventive (c) and-therapeutic effects (d) of naringin on-human-glioma tumor xenografts-grown s.c. naringin (120 mg/ kg/day). The administration began 7-days-before the U-87iinoculation (chemopreventiveeeffect) or 3 days after cell implantation (therapeutic effect). The tumor size was determined twice a week. Daily8average tumor8volumes for each group were8compared throughout the experiment usinggStudent’s t-test. *p < 0.05, **p < 0.01