Conventional high loading dose regimen | Enhanced high loading dose regimen | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
eGFR (ml/min /1.73 m2) | The total dose for the initial 3 days | Maintenance dose after day 3 | eGFR (ml/min /1.73 m2) | The total dose for the initial 3 day | Maintenance dose after day 3 | ||||||
1st day | 2nd day | 3rd day | Total | 1st day | 2nd day | 3rd day | Total | ||||
≥60 | 10 mg/kg twice daily | 10 mg/kg twice daily | 10 mg/kg once daily | 50 mg/kg | 6.7 mg/kg once daily | ≥60 | 12 mg/kg twice daily | 12 mg/kg twice daily | 12 mg/kg once daily | 60 mg/kg | 6.7 mg/kg once daily |
40–60 | 10 mg/kg twice daily | 10 mg/kg once daily | 10 mg/kg once daily | 40 mg/kg | 3.3 mg/kg once daily | 30–60 | 12 mg/kg twice daily | 12 mg/kg once daily | 12 mg/kg once daily | 48 mg/kg | 5.0 mg/kg once daily |
< 40 | 10 mg/kg twice daily | 6.7 mg/kg once daily | 6.7 mg/kg once daily | 33.4 mg/kg | 5.0 mg/kg every 2 days | < 30 | 12 mg/kg twice daily | 12 mg/kg once daily | 6.7 mg/kg once daily | 42.7 mg/kg | 6.7 mg/kg every 2 days |