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Table 3 Significant Risk factors determining odds of being acute vs. chronic Methotrexate toxicity (n = 27)

From: Acute versus chronic methotrexate poisoning; a cross-sectional study

Characteristics

Acute (n = 13)

Chronic (n = 14)

p value

OR (95%CI)

RA Background disease n(%)

3 (23.1)

10 (76.9)

0.021

8.3 (1.4, 47.2)

MTX oral formulation

13 (61.9)

8 (38.1)

0.016

1.8 (1.1, 2.8)

MTX injection formulation

0

5 (100)

0.041

1.6 (1.1, 2.3)

Suicide Attempt n(%)

10 (100)

0

> 0.001

0.23 (0.07, 0.62)

Error in time of prescription drug n(%)

0

5 (100)

0.041

1.6 (1.1, 2.3)

Skin lesions n(%)

0

6 (100)

0.016

1.7 [1.1, 2.7)

Oral ulcerations n(%)

0

13 (100)

> 0.001

14 (2.1, 92.5)

Leukopenia n(%)

1 (7.7)

12 (92.3)

> 0.001

72 (5.7, 904.1)

Thrombocytopenia n(%)

1 (7.7)

14 (100)

> 0.001

15 (2.3, 99.6)

Anemia n(%)

9 (39.1)

14 (60.9)

0.041

0.69 (0.48, 0.99)