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Table 2 Classification of DDIs in the selected sources

From: Countrywide prevalence of critical drug interactions in Hungarian outpatients: a retrospective analysis of pharmacy dispensing data

Name

Categories

Lexicomp Drug Interactions

5 risk ratings:

X – Avoid Combination,

D – Consider Therapy Modification,

C – Monitor Therapy,

B – No Action Needed,

A – No Known Interaction.

3 severity ratings: Major, Moderate, Minor.

4 reliability ratings: Excellent, Good, Fair, Poor.

Medscape Drug Interaction Checker

4 categories:

Contraindicated,

Serious – Use Alternative,

Monitor Closely,

Minor.

Drugs.com

4 categories:

Major – Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.

Moderate – Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.

Minor – Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Unknown – No information available.

Janusmed Interactions

4 clinical relevance ratings:

D – Clinically relevant interaction. The combination is best avoided.

C – Clinically relevant interaction that can be handled e.g. by dose adjustments.

B – Clinical outcome of the interaction is uncertain and/or may vary.

A – Minor interaction of no clinical relevance.

4-point scale for the level of documentation

ORCA

5 classes:

Class 1 – Contraindicated (Risk of combination outweighs benefit),

Class 2 – Provisionally contraindicated (Use only under special circumstances),

Class 3 – Conditional (Assess risk and take actions if needed),

Class 4 – Minimal Risk (Risk of adverse outcome appears small),

Class 5 – No interaction (Evidence suggest that the drugs do not interact).