Name | Categories |
---|---|
Lexicomp Drug Interactions | 5 risk ratings: |
X – Avoid Combination, | |
D – Consider Therapy Modification, | |
C – Monitor Therapy, | |
B – No Action Needed, | |
A – No Known Interaction. | |
3 severity ratings: Major, Moderate, Minor. | |
4 reliability ratings: Excellent, Good, Fair, Poor. | |
Medscape Drug Interaction Checker | 4 categories: |
Contraindicated, | |
Serious – Use Alternative, | |
Monitor Closely, | |
Minor. | |
Drugs.com | 4 categories: |
Major – Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderate – Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minor – Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
Unknown – No information available. | |
Janusmed Interactions | 4 clinical relevance ratings: |
D – Clinically relevant interaction. The combination is best avoided. | |
C – Clinically relevant interaction that can be handled e.g. by dose adjustments. | |
B – Clinical outcome of the interaction is uncertain and/or may vary. | |
A – Minor interaction of no clinical relevance. | |
4-point scale for the level of documentation | |
ORCA | 5 classes: |
Class 1 – Contraindicated (Risk of combination outweighs benefit), | |
Class 2 – Provisionally contraindicated (Use only under special circumstances), | |
Class 3 – Conditional (Assess risk and take actions if needed), | |
Class 4 – Minimal Risk (Risk of adverse outcome appears small), | |
Class 5 – No interaction (Evidence suggest that the drugs do not interact). |