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Table 4 Changes in concentration of serum immunoglobulins at four hour after treatment of Balb-c mice with different doses of test chemicals

From: Study of the principles in the first phase of experimental pharmacology: the basic step with assumption hypothesis

Test chemical

Tested doses

Quantitative immunoassay before treatment as reference test

Quantitative immunoassay at four hour after treatment for comparison

ΔIg serum conc.

IgG

IgM

IgG

IgM

Δ Ig

1.1.Dichlorvos

10 mg/kg

< 1100 mg/L

70 mg/L

< 1100 mg/L

90 mg/L

+ 20 mg/L

50 mg/kg

< 1100 mg/L

70 mg/L

< 1100 mg/L

80 mg/L

+ 10 mg/L

90 mg/kg

X

X

X

X

X

1.1.Chlorpyrifos

10 mg/kg

< 1100 mg/L

90 mg/L

< 1100 mg/L

120 mg/L

+ 30 mg/L

50 mg/kg

< 1100 mg/L

50 mg/L

< 1100 mg/L

70 mg/L

+ 20 mg/L

90 mg/kg

< 1100 mg/L

90 mg/L

< 1100 mg/L

80 mg/L

− 10 mg/L

1.1.Cypermethrin

10 mg/kg

< 1100 mg/L

70 mg/L

< 1100 mg/L

90 mg/L

+ 20 mg/L

50 mg/kg

< 1100 mg/L

80 mg/L

< 1100 mg/L

70 mg/L

− 10 mg/L

90 mg/kg

< 1100 mg/L

80 mg/L

< 1100 mg/L

50 mg/L

− 30 mg/L

  1. Xrepresents treated mouse which died much earlier than the time for blood specimen collection