Table 1 Overview of Nicotine intoxication cases and their toxicological results
CASE | Route IVa or POb | Co intoxication | Amout of *-Nicotine use (mg) | Time to sample (hours) | Plasmatic nicotine level μg/l | Plasmatic cotinine level μg/l | Clinical findings | Issue |
|---|---|---|---|---|---|---|---|---|
Thornton [8] | IV | Amphetamine | 400 | x | 2000 | 2100 | Cardiac asystoly | † |
Sommerfeld Case 1 [9] | Po | none | 372 | 1.5 | 96 | 2800 | Nausea, vomiting, Hypotension, bradycardia | survived |
Sommerfeld Case 2 [9] | IV | Ethanol (70 mg/ml) | 128.8 | 2 | 800 | 2400 | Coma, bradypnea, nausea | survived |
Martin kleish [21] | Po | none | 2288.5 | 2 | 528 | 176 | Tachycardia, hypertension, myosis, abominal pain | survived |
Solarino [10] | Po | Ethanol 2,1 g/l | 1000 (in stomach) | x | 2200 | 2200 | No data | † |
Our case | IV | none | 1000 | 18.5 | 12 | 3200 | tachycardia, coma, bradypnea,mydriasis, myoclonus, flaccid paresia, type 2 NSTEMI | survived |