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Fig. 4 | BMC Pharmacology and Toxicology

Fig. 4

From: Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure

Fig. 4

Effect of pacing and Entinostat treatment on the expression of the potassium channel KCNH2 and the calcium channel Cav1.3 in rabbit hearts. Representative western blots showing protein expression of the Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) (n = 8, control DMSO vs. control Entinostat p < 0.001 (*), control hearts treated with DMSO vs. failing hearts treated with DMSO p < 0.001 (*), failing hearts treated with DMSO vs. failing hearts treated with Entinostat p = 0.043 (*)) (a, b) and the Ca2+ channel Cav1.3 (n = 4, control hearts treated with DMSO vs. control hearts treated with Entinostat p < 0.001 (*), control hearts treated with DMSO vs. failing hearts treated with DMSO p = 0.012 (*)) (c, d). The protein expression was quantified by Living Image Software. All western blots were normalized to DMSO not stimulated = 1

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