Criteria | Selection: Psychiatry consultation or hospitalization | Visit V0: Psychiatry 0–20 days after decision of drug dosage increase | Visit V1: With a nurse Period: 7–21 days after V0 | Visit V2: With a Psychologist or a pratictionner: 25–40 days (4 weeks) after V0 | Visit V3: With a Psychologist or a pratictionner: 50–70 days (8 weeks) after V0 |
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Oral and written Information about the protocol | MARVEL | MARVEL | |||
Verification of inclusion and non inclusion criteria, Signature of informed consent | MARVEL | MARVEL | |||
MADRS and HAM-D | Usual care | MARVEL | MARVEL | ||
Screen for tobacco use | MARVEL | ||||
Renal and liver function | MARVEL | ||||
Characteristics of the mood disorder | MARVEL | ||||
Anxiety scale Tyrer | MARVEL | ||||
Criteria for rating medication trials for antidepressant failure | MARVEL | ||||
QIDS-score | MARVEL | MARVEL | MARVEL | ||
MARS score | MARVEL | MARVEL | MARVEL | ||
PRISE-M score | MARVEL | MARVEL | MARVEL | ||
FIBSER score | MARVEL | MARVEL | MARVEL | ||
Urinary pregnancy test | MARVEL | ||||
Current treatment | MARVEL | MARVEL | MARVEL | MARVEL | |
Recent alimentation | MARVEL | ||||
Blood sample for Css of V and ODV, and mRNA | MARVEL | ||||
Cocktail of drugsa administration | MARVEL | ||||
Blood sample for Phenotypic study | MARVEL | ||||
Total amount of blood for the research | Visit 1 only: 12.5 mL of venous blood and 3 drops of capillary blood sample |