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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Haloperidol affects bones while clozapine alters metabolic parameters - sex specific effects in rats perinatally treated with phencyclidine

Fig. 3

Comparative review of proximal femoral metaphysis in male rats (haematoxylin and eosin, original magnification ×40; arrows point to trabecular area). Histology of the femur in: a) control animals (NaCl); b) animals perinatally treated with phencyclidine (PCP) showing a significant reduction of trabecular area; c) animals perinatally treated with NaCl followed by treatment with haloperidol (NaCl-H) showing a reduction of trabecular area; d) animals perinatally treated with PCP followed by treatment with haloperidol (PCP-H) showing a more profound reduction of trabecular area compared to both NaCl and PCP animals; e) animals perinatally treated with NaCl followed by treatment with clozapine (NaCl-C) showing a significant increase of trabecular area compared to control animals; f) animals perinatally treated with PCP followed by treatment with clozapine (PCP-C) showing a significant increase of trabecular area compared to both NaCl and PCP animals

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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