Fig. 8

Rosiglitazone increased neovascularization and vascular leakage in retina and aorta. Mice were given HFD with or without rosiglitazone (5 mg/kg/day) and injected intraperitoneally with or without Akt inhibitor (0.15 mg/kg, 2 times in a week) for 8 weeks (n = 6/group). a Typical photographs from Evans blue-albumin staining of retina whole-mount from mice. b Microscopic images of retinal flat-mounts and enlarged area. c Microscopic images after injection of Akt inhibitor. d Microscopic image of aortic flat-mounts. e Microscopic images of the enlarged aortic area