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Table 4 Characteristics of study population with and without DRP

From: Drug-related problems and medication reviews among old people with dementia

 

People with DRPs N = 140

People without DRP n = 72

Simple OR (95% CI)

Multiple OR (95% CI)

Cases n (%)

140 (66.0)

72 (33.9)

  

Women, n (%)

88 (62.9)

45 (62.5)

1.015 (0.564-1.827)

 

Age mean ± SD

83.7 ± 6.6

82.0 ± 6.3

1.042 (0.997-1.088)

1.041 (0.994-1.090)

Number of drugs at randomization ± SD

9.3 ± 3.4

6.8 ± 3.4

1.255 (1.137-1.385)

1.241 (1.122-1.374)

Type of ward

 Orthopedic ward n (%)

20 (14.3)

9 (12.5)

ref

 

 Medical ward n (%)

120 (85.7)

63 (87.5)

0.857 (0.369-1.993)

 

Type of living

 Living at home n (%)

91 (65.0)

55 (76.4)

ref

 

 Nursing home n (%)

49 (35.0)

17 (23.6)

1.742 (0.914-3.321)

 

MMSE (0–30) ± SD

18.9 ± 4.8

20.7 ± 4.5

0.923 (0.842-1.013)

 

Creatinine clearance (mL/min)

52.8 ± 22.3

55.0 ± 21.1

0.995 (0.983-1.008)

 

Medical history

 Heart failure n (%)

50 (35.7)

22 (30.6)

1.263 (0.687-2.322)

 

 Cardiac arrhythmia n (%)

40 (28.6)

22 (30.6)

0.909 (0.488-1.692)

 

 Diabetes mellitus n (%)

43 (30.7)

18 (25.0)

1.330 (0.699-2.530)

 

 Chronic obstructive pulmonary disease n (%)

10 (7.1)

6 (8.3)

0.846 (0.295-2.429)

 

 Stroke, past n (%)

44 (31.4)

6 (12.0)

5.042 (2.032-12.509)

4.306 (1.685-11.005)

  1. Abbreviations: CI confidence interval, DRP drug-related problem, MMSE Mini Mental State Examination (n = 157), OR odds ratio, SD standard deviation. Creatinine clearance was based on P-creatinine applying the Cockcroft-Gault equation. The multivariate model includes significant variables as independent variables; number of medications at randomization, stroke and age (borderline significant)