Model | Tissue | Administration route and dose | Effect on AChE activity | Reference |
---|---|---|---|---|
Adult rats | Whole Brain | Intraperitoneal-acute (10–15 mg/kg) and chronic (mg/kg) | Increase | [100] |
Adult rats | Cerebellum | Oral via by drinking water, 30 days (20 mg/ml) | Increase | [189] |
Rats from 21–74 days | Brain | Oral via by food, for 53 days, chronic exposure (500 mg/kg) | Increase | [94] |
Adult mice | Hypothalamus, pons, cerebellum, striatum, medulla, cerebral cortex and hippocampus. | Chronic treatment by oral via from conception to 60 days old | No alterations | [98] |
0-adult rats | Cerebellum and striatum | Oral via by drinking water, 60 days (20 mg/ml) | Increase | [97] |
Adult rats | Brain | Intraperitoneal, 7 days (50 mg/kg) | Increase | [99] |
Adult rats | Whole Brain | Intraperitoneal-(25 mg/kg) in 4 and 8 doses | Decrease | [84] |