Table 4 The pharmacokinetic parameters of plumbagin after oral administration of 100 mg/kg body weight of plumbagin to healthy male Wistar rats [median (interquartile range), n = 4]
From: Pharmacokinetics, toxicity, and cytochrome P450 modulatory activity of plumbagin
Parameter | Plumbagin |
|---|---|
t1/2 (h) | 9.63 (3.04) |
tmax (h) | 5.0 (0.0) |
Cmax (μg/mL) | 0.46 (0.15) |
AUC0-48h (μg∙h/mL) | 6.51 (1.16) |
AUC0−∞ (μg∙h/mL) | 6.71 (1.41) |
MRT (h) | 12.88 (2.49) |
Vd/F (L/mg dose/kg body weight) | 0.0022 (0.00) |
CL/F (L/h/mg dose/kg body weight) | 0.15 (0.3) |