Figure 2From: Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding Substrate profiles of (MOUSE)NAT2*1, (MOUSE)NAT2_R127G and (MOUSE)NAT2_R127L. Substrate specific activity profiles of (MOUSE)NAT2*1 (black columns), (MOUSE)NAT2_R127G (dashed gray columns), (MOUSE)NAT2_R127L (dashed white columns) are shown. Maximal specific activity values (normalised as 100% relative specific activity) are: 196 μM.sec−1.mg−1 for (MOUSE)NAT2*1 with 4ABA, 1385 μM.sec−1.mg−1 for (MOUSE)NAT2_R127G with HDZ and 82.5 μM.sec−1.mg−1 for (MOUSE)NAT2_R127L with 4AV. A dashed line separates aromatic amines from hydrazines. The circles above the bars show the significance of the differences between (MOUSE)NAT2_R127G or (MOUSE)NAT2_R127L and (MOUSE)NAT2*1 (●) and between (MOUSE)NAT2_R127G and (MOUSE)NAT2_R127L (○) using ANOVA with Student’s t-test;● or ○: p ≤0.05; ●● or ○○: p ≤0.01; ●●● or ○○○: p ≤0.001.Back to article page