Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy

Table 4 Timing of selected grade 3 laboratory adverse events

Subject	AE Grade	AE	RBT dose at time of AE	Arm	Days on RBT
148	3	AST increased	150 mg daily	Low-High	106
148	3	Amylase increased	150 mg daily	Low-High	113
171	3	Neutropenia	300 mg daily	Low-High	29
182	3	Neutropenia	300 mg daily	Low-High	27
204	3	Neutropenia	150 mg daily	High-Low	57
204	3	Neutropenia	150 mg tiw	High-Low	112
242	3	Neutropenia	300 mg daily	High-Low	28
242	3	Neutropenia	150 mg daily	High-Low	53
242	3	AST increased	150 mg tiw	High-Low	96
242	3	Amylase increased	150 mg tiw	High-Low	119
250	3	Neutropenia	150 mg daily	Low-High	77

AE – adverse event.
RBT – rifabutin.
ARM – refers to the sequencing order of the rifabutin dosing in combination with ART.
tiw- three times per week.

ISSN: 2050-6511