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Table 3 Pharmacokinetic parameters for lopinavir for each study treatment

From: Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy

 

Median (Interquartile range)

Parameter

RBT 150 mg tiw plus LVP/r

RBT 150 mg daily plus LPV/r

AUC0–12 (μg.h/mL)

139.5 (103.8-163.9)

160.1 (129.1-181.9)

Cmax (ng/mL)

15.8 (12.9-17.1)

18.1 (14.5-19.6)

Tmax (h)

2.0 (2.0-3.0)

2.0 (2.0-3.0)

C0(μg/mL)

9.8 (3.5-14.0)

11.4 (9.9-15.2)

Cmin (μg/mL)

7.4 (4.5-10.0)

9.4 (7.2-11.6)

  1. RBT = rifabutin.
  2. LPV/r = lopinavir/ritonavir.
  3. tiw = three times per week.
  4. AUC = area under the curve.
  5. Cmax = maximum concentration in plasma.
  6. Tmax = time at which maximum plasma attained.
  7. C0 = pre-dose concentration.
  8. Cmin = trough concentration.
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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