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Table 1 Pharmacokinetic parameters for rifabutin and 25- O- desacetylrifabutin for each study treatment

From: Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy

Treatment period

Rifabutin 300 mg

Rifabutin 150 mg tiw plus LPV/r

Rifabutin 150 mg daily plus LPV/r

Rifabutin (n = 14)

   

AUC0–24 (ng.h/mL)

3052.9 (2650.2-3431.5)

2307.5 (1767.5-3884.0)

4766.0 (3950.5-6099.5)

AUC0–48 (ng.h/mL)

6105.8 (5300.4-6863.0)*

3402.1 (2809.2-6092.0)

9532.0 (2238.2-22425.4)*

Cmax (ng/mL)

291.5 (250.0-377.0)

167.5 (87.8-294.0)

311.0 (258.0-376.0)

Tmax (h)

3.0 (3.0-4.0)

3.5 (3.0-5.0)

3.0 (3.0-4.0)

C0 (ng/mL)

59.0 (36.4-78.6)

49.1 (27.7-58.9)

176.5 (149.0-195.0)

Cmin 24 h (ng/mL)

60.7 (40.6-68.8)

70.7 (45.7-96.6)

133.0 (105.0-191.0)

Cmin 48 h (ng/mL)

-

37.0 (26.6-70.0)

-

CL/F (L/h)

98.3 (87.4-113.2)

65.2 (38.6-85.0)

31.5 (25.0-38.0)

AUC0–24 (ng.h/mL) (Rifabutin + Metabolite)

3402.3 (2900.3-3717.2)

3937.2 (2424.6-6772.7)

8753.0 (7771.7-11 505.0)

d-RBT (n = 14)

   

AUC0–24 (ng.h/mL)

273.3 (235.7-344.1)

1565.5 (1105.5-2567.3)

4118.0 (2678.2-5405.5)

AUC0–48 (ng.h/mL)

546.6 (471.4-688.2)*

2318.2 (1722.9-4685.9)

8236.0 (5356.4-10811.0)*

Cmax (ng/mL)

32.5 (25.2-37.7)

77.2 (58.6-128)

236.5 (159.0-274.0)

Tmax (h)

3.0 (3.0-4.0)

5.0 (4.0-6.0)

4.0 (3.0-3.0)

C0 (ng/mL)

5.1 (2.7-6.6)

44.6 (31.7-68.9)

186.0 (115.0-232.0)

Cmin 24 h (ng/mL)

5.0 (3.4 -5.8

63.9 (42.7-101.0)

155.0 (53.6-206.0)

Cmin 48 h (ng/mL)

-

35.4 (27.7-81.0)

-

  1. Parameters are median values (interquartile range).
  2. *calculated by 2X AUC0–24.
  3. RBT = rifabutin.
  4. d-RBT =25-O-desacetylrifabutin.
  5. LPV/r = lopinavir/ritonavir based ART.
  6. tiw = three times per week.
  7. AUC = area under the curve.
  8. Cmax = maximum concentration in plasma.
  9. Tmax = time at which maximum plasma attained.
  10. CL/F = clearance.
  11. C0 = pre-dose concentration.
  12. Cmin = trough concentration.