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Table 2 Multivariate linear regression of the interaction between the change in NPS (0-10) during the CPM-TASK by the treatment group considering the BDNF and pain thresholds (n = 63)

From: Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial

Parameters

Î’

t

P

95% CI

Dependent variable: CPM-TASK

    
 

9.0

1.14

0.01

(4.33 to 32.35)

Treatment group

    
 

Melatonin + Amitriptyline

-1.27

-1.72

0.09

(-2.76 to 0.21)

 

Melatonin

-1.75

-2.5

0.01

(-3.18 to-0.31)

 

Amitriptyline

0b(reference)

   

BDNF (ng/mL)

-0.28

-2.23

0.01

(-0.53 to-0.04)

Heat pain threshold

-8.06

-2.49

0.01

(-14.56 to-1.55)

Interaction

    
 

Serum BDNF (ng/mL) vs. PPT Pain pressure threshold (Kgf/cm2)

0.12

2.07

0.04

(0.04 to 0.24)

  1. bindicates the reference category used to do the comparisons.