Figure 6
Conditional expression of Gα i2 G184S protects the heart from ischemic injury. Conditional expression of Gαi2 G184S significantly (p < 0.001) decreased infarct sizes in hearts exposed to 30 min of ischemia (A). Values represent means ± SE. The number of replicates for each group is shown within the bars. Data were compared by one way ANOVA and posthoc Tukey analysis. *** indicates a significant difference (p < 0.001) compared to hearts isolated from tamoxifen treated Gαi2 fl-G184S/fl-G184S mice, and ### indicates a significant difference (p < 0.001) compared to hearts isolated from Cre-ERT2/Gαi2 fl-G184S/fl-G184S mice that were treated with vehicle instead of tamoxifen. Photographs of representative triphenyltetrazolium chloride-stained hearts are shown in panel B.