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Table 4 Multivariate analysis of the baseline factors associated with changes in antihypertensive drug treatment, CoLaus study

From: Antihypertensive drug treatment changes in the general population: the colaus study

 

Combiners

Switchers

Discontinuers

Women vs. men

0.79 (0.55 - 1.12)

0.94 (0.60 - 1.48)

0.42 (0.21 - 0.81)

ARB (yes vs. no)

0.77 (0.53 - 1.13)

0.31 (0.18 - 0.52)

0.48 (0.23 - 0.98)

Hypertension (yes vs. no)

1.69 (1.18 - 2.42)

1.09 (0.69 - 1.72)

0.66 (0.35 - 1.23)

Treatment regimen

   

 Several pills

1 (ref)

1 (ref)

1 (ref)

 One pill, combination

1.06 (0.63 - 1.79)

1.78 (0.94 - 3.38)

1.48 (0.49 - 4.47)

 One pill, single drug

3.21 (2.06 - 5.00)

1.55 (0.88 - 2.74)

4.06 (1.68 - 9.83)

BMI status

   

 Normal

1 (ref)

1 (ref)

1 (ref)

 Overweight

1.83 (1.13 - 2.95)

0.95 (0.55 - 1.66)

1.52 (0.71 - 3.24)

 Obese

2.35 (1.42 - 3.88)

0.96 (0.53 - 1.76)

0.76 (0.29 - 1.98)

  1. ARB, angiotensin receptor blocker; BMI, body mass index. Statistical analysis by multinomial (polytomous) logistic regression, using continuers as the reference group. Hypertension was defined as a systolic blood pressure ≥140 mm Hg or a diastolic blood pressure ≥90 mm Hg. Results are expressed as relative risk ratio and (95% confidence interval).
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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