Table 1 The doses assigned on the four design levels using the k-adjustment factor and the dose m i at level i
From: The development of response surface pathway design to reduce animal numbers in toxicity studies
Design level I (3 animals) | Design level 2 (5 animals) | Design level 3 (7 animals) | Design level 4 (9 animals) | |||
|---|---|---|---|---|---|---|
Outcome | Dose (m2) | Outcome | Dose (m3) | Outcome | Dose (m4) | Outcome |
0 | m + m/k | 0 | m2 + m/k2 | 0 | m3 + m/k3 | 0 |
1 | m + m/k2 | 1 | m2 + m/k3 | 1 | m3 + m/k4 | 1 |
2 | m - m/k2 | 2 | m2 + m/k4 | 2 | m3 + m/k5 | 2 |
3 | m - m/k | 3 | m2 - m/k4 | 3 | m3 + m/k6 | 3 |
4 | m2 - m/k3 | 4 | m3 - m/k6 | 4 | ||
5 | m2 - m/k2 | 5 | m3 - m/k5 | 5 | ||
6 | m3 - m/k4 | 6 | ||||
7 | m3 - m/k3 | 7 | ||||
8 | ||||||
9 | ||||||