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Figure 3 | BMC Pharmacology and Toxicology

Figure 3

From: The development of response surface pathway design to reduce animal numbers in toxicity studies

Figure 3

The obtained pathway in the simulated Yessotoxin study using the optimised 4-level RSP design. The optimised 4-level RSP design incorporates multinomial outcome, used k-adjustment factor and increasing number of mice with increasing design levels, and the pathway obtained in the simulation study is shown by dashed line. The doses are given in μg/kg BW and the numbers in the callouts represent the ratios of dead mice.

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