From: Pharmacokinetic interaction of ketoconazole, clarithromycin, and midazolam with riociguat
Midazolam/riociguat study | ||||
---|---|---|---|---|
 | Midazolam (n=22) | Midazolam + riociguat 2.5 mg (n=22) | ||
Parameter | GM | %CV | GM | %CV |
AUC (µg·h/L) | 91.1 | 34.3 | 98.2 | 37.0 |
Cmax (µg/L) | 29.0 | 45.1 | 29.5 | 41.5 |
t1/2 (h) | 4.5 | 35.9 | 4.3 | 34.9 |