From: Pharmacokinetic interaction of ketoconazole, clarithromycin, and midazolam with riociguat
 | Riociguat/ketoconazole study | Riociguat/clarithromycin study | ||||||
---|---|---|---|---|---|---|---|---|
Parameter | Riociguat 0.5 mg (n=16) | Riociguat 0.5 mg + ketoconazole (n=16) | Riociguat 1 mg (n=14) | Riociguat 1 mg + clarithromycin (n=14) | ||||
 | GM | %CV | GM | %CV | GM | %CV | GM | %CV |
AUC (µg·h/L) | 81.9 | 78.6 | 204.9 | 44.9 | 171.1 | 97.0 | 240.0 | 88.9 |
Cmax (µg/L) | 9.4 | 29.9 | 13.7 | 19.3 | 20.8 | 37.7 | 21.6 | 33.9 |
t1/2 (h) | 7.3 | 78.5 | 9.2 | 57.1 | 6.4 | 77.1 | 7.9 | 54.6 |
CL/f (L/h) | 6.1 | 78.6 | 2.4 | 44.9 | 5.8 | 97.0 | 4.2 | 88.9 |