Table 2 PK parameters for each patient
Patient | Cmax(μg/mL) | Cmin(μg/mL) | VD (L/kg) | Ke (h–1) | CL (L/h) | t1/2(h) | AUC [0-inf] | Dose in mg/kg |
|---|---|---|---|---|---|---|---|---|
1 | 283.97 | 13.29 | 0.26 | 0.53 | 7.45 | 1.31 | 398.78 | 54.05 |
2 | 200.56 | 16.87 | 0.35 | 0.44 | 8.70 | 1.59 | 419.14 | 52.63 |
4 | 337.21 | 6.36 | 0.22 | 0.69 | 8.15 | 1.01 | 232.15 | 70.18 |
5 | 211.53 | 18.76 | 0.35 | 0.43 | 8.19 | 1.60 | 446.61 | 46.51 |
6 | 153.13 | 18.74 | 0.61 | 0.36 | 9.30 | 1.95 | 311.08 | 85.11 |
7 | 97.37 | 3.88 | 0.52 | 0.57 | 23.54 | 1.21 | 163.28 | 63.49 |
8 | 94.10 | 2.22 | 0.65 | 0.64 | 27.25 | 1.08 | 115.12 | 58.82 |
10 | 465.78 | 13.64 | 0.15 | 0.57 | 4.93 | 1.21 | 607.15 | 86.96 |
11 | 162.34 | 5.18 | 0.42 | 0.53 | 13.13 | 1.30 | 317.32 | 66.67 |
12 | 179.52 | 37.65 | 0.45 | 0.26 | 5.84 | 2.65 | 418.48 | 60.61 |
13 | 318.81 | 28.34 | 0.26 | 0.44 | 5.48 | 1.59 | 667.45 | 62.50 |
14 | 319.55 | 19.07 | 0.30 | 0.50 | 6.20 | 1.40 | 477.15 | 78.43 |
15 | 513.74 | 4.52 | 0.10 | 0.82 | 6.38 | 0.85 | 678.99 | 86.96 |
16 | 1133 | 0.47 | 0.08 | 1.25 | 4.42 | 0.55 | 827.16 | 66.67 |
Mean | 319.33 | 13.50 | 0.34 | 0.57 | 9.93 | 1.38 | 434.28 | 67.11 |
σ(n-1) | 266.08 | 10.71 | 0.18 | 0.24 | 6.95 | 0.51 | 205.17 | 13.01 |