Table 3 Pharmacokinetic parameters of CR8 in different organs following single oral administration of 100 mg/kg
From: Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice
Plasma | Liver | Adipose tissue | Kidney | Lung | Spleen | Bone marrow | Brain | |
|---|---|---|---|---|---|---|---|---|
AUC (μg.hr/g) | 96 | 197 | 181 | 145 | 77 | 40 | 34 | 14 |
Beta-HL (hr) | 3.10 | 2.43 | 2.40 | 2.62 | 2.58 | 2.60 | 1.98 | 2.12 |
Cmax (μg/ml) | 34.3 | 52.4 | 48.7 | 36.0 | 19.3 | 27.7 | 10.6 | 4.1 |
CL/F | 21.0 | 10.2 | 11.1 | 13.8 | 26.2 | 20.0 | 29.5 | 146.0 |
V2/F | 21.0 | 35.8 | 38.2 | 52.2 | 96.7 | 74.5 | 84.5 | 447.5 |