Figure 6
From: Raltegravir does not revert efflux activity of MDR1-P-glycoprotein in human MDR cells
MDR1-Pgp drug induction assay. In the left part of the figure, the shift of the MDR1-Pgp binding profile (shaded histogram) is parallel with the increase of VBL concentration. In the right part of the figure, RALT treatment is ineffective in all tested concentrations in up-modulating the MDR1-Pgp expression (empty histogram). In both experiments the highly specific mAb MM4.17 was used for staining procedures.