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Table 2 KLF4 mRNA fold changes in H9C2 from the gene microarrays and subsequent confirmation using qRT-PCR

From: Assessing the translatability of In vivo cardiotoxicity mechanisms to In vitro models using causal reasoning

 

qRT-PCR

Affymetrix

Amiodarone

2.2

1.62

Amitryptiline

2.8

2.3

Cyclosporine

2.1

1.84

Dexamethasone

1.3

2.14

Dobutamine

1.7

1.93

Doxorubicin

−9.7*

−4.92*

Loratadine

2.4

2.1

Mitoxantrone

1.4

2.06

  1. *The decreased levels in Doxorubicin might be a reflection of severe cytotoxicity. However, KLF4 measurement at a lower dose (IC20 instead of IC50) resulted in 2.52 fold increase.
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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