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Table 2 Parameter estimates of the anakinra effect on c-reactive protein concentrations in 22 SJIA patients (RESP = responders and RESI = patients with onset of “resistance” to treatment)

From: Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes

Parameter

Estimate

Relative standard error (%)

Baseline (mg/L)

  

 RESP

141

27

 RESI

37.9

29

kTR (day-1)

0.042

27

C50 (mg/L)

0.03

37

kRESI (day-1)

0.0048

0.0018

Proportion of RESP

0.37

31

ηBASELINE.RESI

0.79

24

ηKTR

081

25

ϵ, mg/L (*)

0.39

6

  1. Key: Baseline, CRP level before treatment; k TR , transit time rate constant; C 50 , anakinra concentration that induces a 50% decrease of CRP level; k RESI , time rate constant of resistance appearance; η, between-subject variability; ϵ, constant residual variability, *log-additive model.
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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