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Table 1 Parameter estimates of the final anakinra population pharmacokinetic model in 87 pediatric patients

From: Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes

Parameter

Estimate

Relative standard error (%)

CL/F (L h-1 70 kg-1)

6.24

8

βCL, TV(CL)∙(BW/70)βCL

0.47

14

V/F (L)

65.2

12

βV, TV(V)∙(BW/70)βV

0.76

16

Ka (h-1)

0.38

19

ηCL/F

0.28

15

γV/F

0.47

17

ϵ, mg/L

0.072

10

  1. Key: CL/F, apparent elimination clearance; V/F, apparent volume of distribution; Ka, absorption rate constant; F, unknown bioavailability; TV(), typical value for the mean covariate value; β, covariate effect parameter; η, between-subject variability; γ, between occasion variability; ϵ, constant residual variability; BW, bodyweight (CL/F and V/F estimates are normalized to a 70 kg BW).
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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